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KMID : 0380020140290060405
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Korean Journal of Biotechnology and Bioengineering
2014 Volume.29 No. 6 p.405 ~ p.413
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Preparation of Gemcitabine-Loaded PLLA/Gemcitabine-PLLA Microparticles Using Supercritical Fluid and Their Release Characteristics
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Hong Jin-Hee
Lim Gio-Bin
Ryu Jong-Hoon
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Abstract
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In this study, gemcitabine (Gem)-Poly(L-lactic acid) (PLLA) conjugates were synthesized through an amide linkage reaction. Then, the microparticles of Gem-PLLA/PLLA blends containing gemcitabine were prepared using a supercritical fluid process, called aerosol solvent extraction system (ASES). Gemcitabine-loaded Gem-PLLA/PLLA microparticles obtained from the ASES process showed a spherical shape. The amount of gemcitabine released after 30 day incubation in a phosphate buffer solution of pH 7.4 was about 90% of the total amount of gemcitabine present in the product.
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KEYWORD
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Drug-polymer conjugate, Gemcitabine, Poly(L-lactic acid), Supercritical carbon dioxide, Aerosol solvent extraction system
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